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Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line
Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as th...
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| Formato: | Dissertation |
| Idioma: | inglês |
| Publicado em: |
Philipps-Universität Marburg
2015
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| Acesso em linha: | Texto integral em PDF |
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| Resumo: | Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as the janus kinase 2 gene. A combination of the coiled-coil dimerization domain of BCR and the JH1 tyrosine kinase domain of JAK2 generates a tumouringenic fusion protein capable of inducing Il-3 independent proliferation in an IL-3 dependent cell line. |
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| DOI: | 10.17192/z2015.0626 |