Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line

Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line

Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as th...

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Bibliographic Details
Main Author: Marbach, Felix
Contributors: Bohlander, Stefan (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2015
Subjects:
Translokation
Fusion gene
Leukämie
Medical applications (general)
Tumor
Klonierung
Protein-Tyrosin-Kinasen
Tyrosinkinase-Inhibitor
Medizin
Onkogen
Mutation
Fusionsgen
Tyrosine kinase inhibitor
Medical sciences Medicine
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Summary:Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as the janus kinase 2 gene. A combination of the coiled-coil dimerization domain of BCR and the JH1 tyrosine kinase domain of JAK2 generates a tumouringenic fusion protein capable of inducing Il-3 independent proliferation in an IL-3 dependent cell line.
DOI:10.17192/z2015.0626

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