Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line

Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line

Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as th...

Fuld beskrivelse

Gespeichert in:
Bibliografiske detaljer
Hovedforfatter: Marbach, Felix
Andre forfattere: Bohlander, Stefan (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprog:engelsk
Udgivet: Philipps-Universität Marburg 2015
Fag:
Fusion gene
Translokation
Leukämie
Medical applications (general)
Tumor
Klonierung
Fusionsgen
Tyrosine kinase inhibitor
Protein-Tyrosin-Kinasen
Medizin
Onkogen
Tyrosinkinase-Inhibitor
Mutation
Medical sciences Medicine
Online adgang:PDF-Volltext
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
Beskrivelse
Summary:Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as the janus kinase 2 gene. A combination of the coiled-coil dimerization domain of BCR and the JH1 tyrosine kinase domain of JAK2 generates a tumouringenic fusion protein capable of inducing Il-3 independent proliferation in an IL-3 dependent cell line.
DOI:10.17192/z2015.0626

Lignende værker