Insights into Protein-Ligand Molecular Recognition: Thermodynamic, Kinetic and Structural Characterization of Inhibitor Binding to Aldose Reductase and Carbonic Anhydrase II

Two pathological relevant proteins, human aldose reductase and human carbonic anhydrase, were used as model proteins to get insights into the process of molecular recognition. The thermodynamics and kinetics of the formation process of protein ligand complex formation were studied.

Détails bibliographiques

Auteur principal:	Rechlin, Chris
Autres auteurs:	Klebe, Gerhard (Prof. Dr.) (Directeur de thèse)
Format:	Dissertation
Langue:	anglais
Publié:	Philipps-Universität Marburg 2015
Sujets:	Medizin Ligand Kinetic Proteins Thermodynamic Kinetik Drug Design Thermodynamik Arzneimitteldesign Proteine Medical sciences Medicine
Accès en ligne:	Texte intégral en PDF
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