Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

The signalling pathway from G-protein-coupled receptors to the second messenger cAMP is present in virtually all cells and of major physiological and pathophysiological importance. The membrane-spanning receptors can easily be targeted by pharmaceutical compounds and therapies to treat diseases like...

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Bibliografiske detaljer
Hovedforfatter: Milde, Markus
Andre forfattere: Bünemann, Moritz (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprog:engelsk
Udgivet: Philipps-Universität Marburg 2013
Fag:
Dynamik
Adenylylzyklase
cAMP
interaction
G-protein
adenylyl cyclase
Interaktion
Fluoreszenz-Resonanz-Energie-Transfer
G-Protein
Medizin
FRET
Medical sciences Medicine
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Klassifikationsnummer: urn:nbn:de:hebis:04-z2013-03902
Publikationsdatum: 2013-08-14
Datum der Annahme: 2013-07-17
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2013/0390
https://doi.org/10.17192/z2013.0390

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