Publikationsserver
The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry
The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...
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| Formato: | Dissertation |
| Idioma: | inglés |
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Philipps-Universität Marburg
2012
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| Schlagworte: | |
| Acceso en liña: | Texto completo PDF |
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