The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...

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Kaydedildi:
Detaylı Bibliyografya
Yazar: Biela, Adam
Diğer Yazarlar: Klebe, Gerhard (Prof. Dr.) (Tez danışmanı)
Materyal Türü: Dissertation
Dil:İngilizce
Baskı/Yayın Bilgisi: Philipps-Universität Marburg 2012
Konular:
Thrombin
Medizin
ITC
Water Network
Thermolysin
Hydrophobic Effect
Wassernetzwerk
Hydrophober Effekt
Medical sciences Medicine
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