Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

The transcription factor interferon regulatory factor (IRF) 1 is essential for T helper cell 1 differentiation. Hereby, the respective Irf1 knockout mouse displays a severe immune defect and has an Th2 directed immune status per se. This effect is measurable by increased production of interleukin-4,...

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Bibliographic Details
Main Author: Mahiny, Azita Josefine
Contributors: Lohoff, Michael (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2011
Subjects:
Cre-lox
knockout mouse
IRF4
Biowissenschaften, Biologie
Knockout-Maus
T cells
IRF1
T Zellen
Life sciences
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Call Number: urn:nbn:de:hebis:04-z2011-05618
Publication Date: 2011-09-06
Date of Acceptance: 2011-08-26
Downloads: 48 (2024), 90 (2023), 138 (2022), 81 (2021), 71 (2020), 60 (2019), 27 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2011/0561
https://doi.org/10.17192/z2011.0561

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