Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Bibliografische gegevens

Hoofdauteur:	Craan, Tobias Friedrich
Andere auteurs:	Klebe, Gerhard (Prof. Dr.) (Thesis begeleider)
Formaat:	Dissertation
Taal:	Engels
Gepubliceerd in:	Philipps-Universität Marburg 2011
Onderwerpen:	Fragmentbibliotek Fragment Naturwissenschaften FBLD Fragmentbasierte Leitstrukturentwicklung Fragment library Natural sciences & mathematics
Online toegang:	PDF Full text
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