The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The presented study contributes to the fundamental understanding of molecular recognition of small molecules by a macromolecular host protein. The biophysical properties of a large set of systematically varied thrombin inhibitors were anatomized in detail. In particular the combination of structural...

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Bibliographic Details
Main Author: Baum, Bernhard
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2009
Subjects:
Mikrokalorimetrie
Kristallographie
Thrombin
Wirkstoffdesign
Structure based drug-design
Arzneimitteldesign
Naturwissenschaften
Thermodynamik
Natural sciences & mathematics
Online Access:PDF Full Text
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