The histone acetyl transferase Tip60 as a regulator of tumor suppression

The histone acetyl transferase Tip60 as a regulator of tumor suppression

Tip60 is a histone acetyl transferase (HAT) and a cofactor of transcription, but also an interaction partner of the Mdm2 oncoprotein. The functional consequences of this interaction are only partially understood and were further explored in this study. We found that Tip60 expression leads to an incr...

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Bibliographic Details
Main Author: Dohmesen, Christoph
Contributors: Bölker, Michael (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2007
Subjects:
His-tag-Pulldown
Biowissenschaften, Biologie
UV-irradiation
Apoptosis
Neddylierung
Neddylation
Tumorsuppressor-Gen
Protein MDM2
Ubiquitin-like modifiers
Histon-Acetyltransferase
Protea
Ubiquitin-ähnliche Proteine
PML nuclear bodies
Ubiquitin-Protein-Ligase
Protein TIP60, NEDD8
Histone acetyl transferase
Ultraviolett-Bestrahlung
Protein p53
Life sciences
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