Characterization of Binding Pocket Flexibility of Aldose Reductase

Aldose Reductase (AR) is the first enzyme of the 'sorbitol pathway'. It is an NADPH dependent enzyme and catalyzes the reduction of various aldehydes to the corresponding alcohols. Its binding pocket shows intrinsic flexibility which is mainly mediated by a small loop region. A specificity...

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主要作者: Zentgraf, Matthias
其他作者: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
格式: Dissertation
語言:英语
出版: Philipps-Universität Marburg 2006
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