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Characterization of Binding Pocket Flexibility of Aldose Reductase
Aldose Reductase (AR) is the first enzyme of the 'sorbitol pathway'. It is an NADPH dependent enzyme and catalyzes the reduction of various aldehydes to the corresponding alcohols. Its binding pocket shows intrinsic flexibility which is mainly mediated by a small loop region. A specificity...
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| Format: | Dissertation |
| Sprog: | engelsk |
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Philipps-Universität Marburg
2006
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| Online adgang: | PDF-Volltext |
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