Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse

Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse

Die Aufgabe der für die Immunantwort und den Knochenstoffwechsel entscheidenden TNF-Liganden und -Rezeptoren-Familienmitglieder RANKL, OPG und RANK war in der Pathophysiologie und Physiologie der Schilddrüse lange ungeklärt. Die Ergebnisse dieser Arbeit zeigen, dass die Schilddrüse sowohl ein Ort de...

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Bibliografski detalji
Glavni autor: Kluger, Sibylle
Daljnji autori: Hofbauer, L. C. (Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:njemački
Izdano: Philipps-Universität Marburg 2005
Teme:
OPG
Dendritic cells
Dendritische Zellen
RANKL
Basedow-Krankheit
Thyroid
Autoimmun diseases
Medizin
Schilddrüse
Autoaggressionskrankheit
Medical sciences Medicine
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Receptor activator of NF-kB-Ligand (RANKL) and osteoprotegerin (OPG) play essential roles in bone metabolism and immun responses. RANKL activates RANK, wich is expressed by osteoclasts and dendritic cells, whereas OPG acts as its decoy receptor. The role of RANKL and OPG in thyroid physiologie remainded unclear. The shown data suggest that RANKL and OPG are produced in the thyroid galnd by thyroid follicular cells, are regulated by cytokines and TSHm, and are capable of modulating dendritic cell functions. Thus, these cytokines may represent important local immunmregulatory factors involved in the pathogenesis of autoimmun thyroid diseases.

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