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Case report: Unilateral GPi DBS in secondary myoclonus-dystonia syndrome after acute disseminated encephalomyelitis
Introduction: Deep brain stimulation (DBS) is an established and effective therapy for movement disorders. Here, we present a case of secondary myoclonusdystonia syndrome following acute disseminated encephalomyelitis (ADEM) in childhood, which was alleviated by DBS. Using a patient-specific conn...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
Philipps-Universität Marburg
2023
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | পিডিএফ এ সম্পূর্ন পাঠ |
| ট্যাগগুলো: |
ট্যাগ যুক্ত করুন
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| সংক্ষিপ্ত: | Introduction: Deep brain stimulation (DBS) is an established and effective therapy
for movement disorders. Here, we present a case of secondary myoclonusdystonia
syndrome following acute disseminated encephalomyelitis (ADEM) in
childhood, which was alleviated by DBS. Using a patient-specific connectome
analysis, we sought to characterise the fibres and circuits affected by stimulation.
Case report: We report a case of a 20-year-old man with progressive dystonia,
myoclonic jerks, and impaired concentration following childhood ADEM. Motor
assessments utilising the Unified Myoclonus Rating Scale (UMRS) and the Burke-
Fahn-Marsden Dystonia Rating Scale (BFMDRS) revealed a greater improvement
in dystonia compared to myoclonus following adjustments of DBS parameters.
These adjustments were based on visualisation of electrode position and volume
of tissue activated (VTA) 3 years after surgery. A patient-specific connectome
analysis using the VTA as a region of interest revealed fibre tracts connecting to
the cerebello-thalamo-cortical network and the superior frontal gyrus in addition
to basal ganglia circuits as particularly effective.
Conclusion: Globus pallidus internus (GPi) DBS shows promise as a treatment
for secondary myoclonus-dystonia syndromes. Personalised structural
considerations, tailored to individual symptoms and clinical characteristics, can
provide significant benefits. Patient-specific connectome analysis, specifically,
offers insights into the structures involved and may enable a favourable treatment
response. |
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| উপাদানের বিবরণ: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| ডিওআই: | 10.3389/fneur.2023.1238743 |