Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics are considered a promising treatment strategy in the management of LASV disease. Methods: We used chimeric Ifnar?/? C57B...

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Auteurs principaux:	Oestereich, Lisa, Müller-Kräuter, Helena, Pallasch, Elisa, Strecker, Thomas
Format:	Article
Langue:	anglais
Publié:	Philipps-Universität Marburg 2023
Sujets:	Medizin neutralizing antibodies; in vivo protection arenavirus Lassa mammarenavirus virus-like particle Lassa fever Medical sciences Medicine
Accès en ligne:	Texte intégral en PDF
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