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Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis
In a recent study published in Nature, Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylation (OXPHOS), which drives the invasive spread of cancer cells. The inhibition of...
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| Autoren: | , |
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| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Philipps-Universität Marburg
2022
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| Online-Zugang: | PDF-Volltext |
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| Zusammenfassung: | In a recent study published in Nature, Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylation (OXPHOS), which drives the invasive spread of cancer cells. The inhibition of one particular RNA-modifying enzyme was sufficient to prevent the cancer cell invasion and dissemination.
Glycolysis and OXPHOS are two main metabolic pathways that support cancer cell development and progression. While primary tumors preferentially utilize glucose as a source for their energetic requirement (aerobic glycolysis, also known as the Warburg effect that is in general a hallmark of tumor metabolism), less is known about metabolic plasticity required for dissemination of cancer cells from primary tumor sites. Metastasis, which is a multistep process enabling the tumor cells to spread from primary tumors to adjacent and distinct tissues, is responsible for approximately 90% of cancer-related deaths. The metastatic development requires cancer cells to leave the primary tumors and to metabolically adopt to changing microenvironment. |
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| Beschreibung: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.1038/s41392-022-01205-6 |