IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model

In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8+ cytotoxic T cells (CTLs) is an important factor in determining prognosis. The migration pattern and interaction behavior of intratumoral CTLs are pivotal to tumor rejection. NLRP3-dependent proinflammatory cytokines IL-1β and IL-18...

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Autoren:	Nasiri, Elena, Student, Malte, Roth, Katrin, Siti Utami, Nadya, Huber, Magdalena, Buchholz, Malte, Gress, Thomas M., Bauer, Christian
Format:	Artikel
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2023
Schlagworte:	intravital two-photon microscopy animal models for intravital imaging cytokines T-cell plasticity T-cell migration Medizin fluorophore pancreatic carcinoma pausing phases/arrest coefficient live cell imaging tumor spheroid coculture model Medical sciences Medicine
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