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The effect of self-generated versus externally generated actions on timing, duration, and amplitude of blood oxygen level dependent response for visual feedback processing
It has been widely assumed that internal forward models use efference copies to cre-ate predictions about the sensory consequences of our own actions. While these pre-dictions have frequently been associated with a reduced blood oxygen leveldependent (BOLD) response in sensory cortices, the timing a...
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| Autoren: | , , , , |
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| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Philipps-Universität Marburg
2022
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| Schlagworte: | |
| Online Zugang: | PDF-Volltext |
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| Zusammenfassung: | It has been widely assumed that internal forward models use efference copies to cre-ate predictions about the sensory consequences of our own actions. While these pre-dictions have frequently been associated with a reduced blood oxygen leveldependent (BOLD) response in sensory cortices, the timing and duration of thehemodynamic response for the processing of video feedback of self-generated(active) versus externally generated (passive) movements is poorly understood. In thepresent study, we tested the hypothesis that predictive mechanisms for self-generated actions lead to early and shorter neural processing compared with exter-nally generated movements. We investigated active and passive movements using acustom-made fMRI-compatible movement device. Visual video feedback of theactive and passive movements was presented in real time or with variable delays.Participants had to judge whether the feedback was delayed. Timing and duration ofBOLD impulse response was calculated using a first (temporal derivative [TD]) andsecond-order (dispersion derivative [DD]) Taylor approximation. Our reanalysis con-firmed our previous finding of reduced BOLD response for active compared to pas-sive movements. Moreover, we found positive effects of the TD and DD in thesupplementary motor area, cerebellum, visual cortices, and subcortical structures,indicating earlier and shorter hemodynamic responses for active compared to passivemovements. Furthermore, earlier activation in the putamen for active compared topassive conditions was associated with reduced delay detection performance. Thesefindings indicate that efference copy-based predictive mechanisms enable earlierprocessing of action feedback, which might have reduced the ability to detect shortdelays between action and feedback. |
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| Beschreibung: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.1002/hbm.26053 |