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Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(R) using terahertz time-domain spectroscopy
We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its α- crystalline form and t...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | inglês |
| Publicado em: |
Philipps-Universität Marburg
2022
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| Assuntos: | |
| Acesso em linha: | Texto Completo em Formato PDF |
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| Resumo: | We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its α- crystalline form and the amount of A-IM in the smartFilms reduces. Both, α- and A-IM are preferred over the more common γ- crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug. |
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| Descrição do item: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.1038/s41598-022-10041-1 |