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Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(R) using terahertz time-domain spectroscopy

We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its α- crystalline form and t...

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Bibliographic Details
Main Authors: Ornik, Jan, Heidrich, Lara, Schesny, Robert, Castro-Camus, Enrique, Keck, Cornelia M., Koch, Martin
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
Physik
Physics
Online Access:PDF Full Text
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Summary:We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its α- crystalline form and the amount of A-IM in the smartFilms reduces. Both, α- and A-IM are preferred over the more common γ- crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug.
Item Description:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
DOI:10.1038/s41598-022-10041-1

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