Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the car...

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Autori principali: Amin, Muhammad Umair, Ali, Sajid, Alie, Muhammad Yasir, Fuhrmann, Dominik C., Tarik, Imran, Seitz, Benjamin S., Preis, Eduard, Büßler, Jana, Brüne, Bernhard, Bakowsky, Udo
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2023
Soggetti:
Pharmakologie, Therapeutik
Hypoxia
mesoporous silica nanoparticles
liposomes
co-delivery
CA-IX enzyme inhibition
Pharmacology & therapeutics, prescription drugs
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