Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and ope...

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Detalles Bibliográficos

Autoren:	Polo, Pierfrancesco, Gremke, Niklas, Stiewe, Thorsten, Wanzel, Michael
Formato:	Artigo
Idioma:	inglés
Publicado:	Philipps-Universität Marburg 2023
Schlagworte:	metabolic cancer ther autophagy haploinsufficiency cancer metabolism Medizin copy number loss somatic copy number alterations (SCNAs) aerobic glycolysis Medical sciences Medicine
Acceso en liña:	Texto completo PDF
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