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Robustness of the Autophagy Pathway to Somatic Copy Number Losses

Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore mark a metabolically vulnerable cancer state and ope...

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Autors principals: Polo, Pierfrancesco, Gremke, Niklas, Stiewe, Thorsten, Wanzel, Michael
Format: Article
Idioma:anglès
Publicat: Philipps-Universität Marburg 2023
Matèries:
metabolic cancer ther
autophagy
haploinsufficiency
cancer metabolism
Medizin
copy number loss
somatic copy number alterations (SCNAs)
aerobic glycolysis
Medical sciences Medicine
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Signatura: urn:nbn:de:hebis:04-es2023-00175
Data de publicació: 2023-03-06
Font: Erstveröffentlichung: Polo, P.; Gremke, N.; Stiewe, T.;Wanzel, M. Robustness of the Autophagy Pathway to Somatic Copy Number Losses. Cells 2022, 11, 1762. https://doi.org/10.3390/cells11111762
Downloads: 6 (2025), 45 (2024), 28 (2023)
Lizenz: https://creativecommons.org/licenses/by/4.0
URL d'accés: https://archiv.ub.uni-marburg.de/es/2023/0017
https://doi.org/10.3390/cells11111762

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