PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

: This study aims to design a pH-responsive dual-loaded nanosystem based on PEGylated chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX) for the effective treatment of breast cancer. In this regard, non-PEGylated and PEGylated chitosan nanoparticles (CS NPs) loaded with ei...

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Autoren: Fahmy, Sherif Ashraf, Ramzy, Asmaa, Mandour, Asmaa A., Nasr, Soad, Abdelnaser, Anwar, Bakowsky, Udo, Azzazy, Hassan Mohamed El-Said
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2022
Schlagworte:
breast cancer
PEG
Medizin
ionic gelation method
chitosan nanoparticles
ascorbic acid (vitamin C)
oxaliplatin
Medical sciences Medicine
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Signatur: urn:nbn:de:hebis:04-es2022-01523
Publikationsdatum: 2022-09-01
Quelle: Erstveröffentlichung: Fahmy, S.A.; Ramzy, A.; Mandour, A.A.; Nasr, S.; Abdelnaser, A.; Bakowsky, U.; Azzazy, H.M.E.-S. PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells. Pharmaceutics 2022, 14, 407. https://doi.org/10.3390/pharmaceutics14020407
Downloads: 29 (2024), 42 (2023), 9 (2022)
Lizenz: https://creativecommons.org/licenses/by/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2022/0152
https://doi.org/10.3390/pharmaceutics14020407

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