Toward Novel [18F]Fluorine-labeled Radiotracers for the Imaging of α-Synuclein Fibrils

Toward Novel [18F]Fluorine-labeled Radiotracers for the Imaging of α-Synuclein Fibrils

The accumulation of α-synuclein aggregates (α-syn) in the human brain is an occurrence common to all α-synucleinopathies. Non-invasive detection of these aggregates in a living brain with a target-specific radiotracer is not yet possible. We have recently discovered that the inclusion of a methylene...

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Huvudupphovsmän: Uzuegbunam, Bright C., Li, Junhao, Paslawsk, Wojciech, Weber, Wolfgang, Svenningsson, Per, Ågren, Hans, Yousefi, Behrooz Hooshyar
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2022
Ämnen:
PET tracer development
disaryl
Medizin
positron emission tomography (PET)
α-synucleinopathies
α-synuclein aggregates
ruthenium-mediated deoxyfluorination
Medical sciences Medicine
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Signum: urn:nbn:de:hebis:04-es2022-01463
Utgivningstid: 2022-08-31
Källa: Erstveröffentlichung: Uzuegbunam BC, Li J, Paslawski W, Weber W, Svenningsson P, Ågren H and Yousefi BH (2022
Downloads: 37 (2024), 34 (2023), 2 (2022)
Lizenz: https://creativecommons.org/licenses/by/4.0
Länk till materialet: https://archiv.ub.uni-marburg.de/es/2022/0146
https://doi.org/10.3389/fnagi.2022.830704

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