Characterization of the transcriptional repressor SAMD1 in hepatocellular carcinoma and pancreatic ductal adenocarcinoma
Until now, the protein SAMD1 had remained largely unexplored. However, recently, we identified SAMD1 as a novel CpG island-binding protein. SAMD1 directly interferes with unmethylated CpG-rich DNA via an atypical winged-helix domain, simultaneously engaging both the major and minor DNA groove. This...
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Materiálatiipa: | Dissertation |
Giella: | eaŋgalasgiella |
Almmustuhtton: |
Philipps-Universität Marburg
2023
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Liŋkkat: | PDF-ollesdeaksta |
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