Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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主要作者: Knoll Machado, Steffi
其他作者: Bacher, Michael (Professor) (BetreuerIn (Doktorarbeit))
格式: Dissertation
語言:英语
出版: Philipps-Universität Marburg 2023
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索引號: urn:nbn:de:hebis:04-z2023-03593
Publikationsdatum: 2023-12-21
Datum der Annahme: 2023-04-27
Downloads: 52 (2024), 1 (2023)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359