Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Detalhes bibliográficos
Autor principal: Knoll Machado, Steffi
Outros Autores: Bacher, Michael (Professor) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2023
Assuntos:
Medizin
Faktor 9
rekombinantes Protein ,
Hämophilie B
factor 9
Hemophilia B
Gerinnungsfaktor IX
Medical sciences Medicine
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Detalhes do Exemplar
Área/Cota: urn:nbn:de:hebis:04-z2023-03593
Publikationsdatum: 2023-12-21
Datum der Annahme: 2023-04-27
Downloads: 52 (2024), 1 (2023)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359

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