Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Kaituhi matua: Knoll Machado, Steffi
Ētahi atu kaituhi: Bacher, Michael (Professor) (BetreuerIn (Doktorarbeit))
Hōputu: Dissertation
Reo:Ingarihi
I whakaputaina: Philipps-Universität Marburg 2023
Ngā marau:
Medizin
Faktor 9
rekombinantes Protein ,
Hämophilie B
factor 9
Hemophilia B
Gerinnungsfaktor IX
Medical sciences Medicine
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Tau karanga: urn:nbn:de:hebis:04-z2023-03593
Rā whakaputa: 2023-12-21
Datum der Annahme: 2023-04-27
Downloads: 52 (2024), 1 (2023)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL Uru: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359

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