Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Bibliografski detalji
Glavni autor: Knoll Machado, Steffi
Daljnji autori: Bacher, Michael (Professor) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2023
Teme:
Medizin
Faktor 9
rekombinantes Protein ,
Hämophilie B
factor 9
Hemophilia B
Gerinnungsfaktor IX
Medical sciences Medicine
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Signatura: urn:nbn:de:hebis:04-z2023-03593
Datum izdanja: 2023-12-21
Datum der Annahme: 2023-04-27
Downloads: 53 (2024), 1 (2023)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL pristupa: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359

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