Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Bibliographic Details
Main Author: Knoll Machado, Steffi
Contributors: Bacher, Michael (Professor) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
Medizin
Faktor 9
rekombinantes Protein ,
Hämophilie B
factor 9
Hemophilia B
Gerinnungsfaktor IX
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2023-03593
Publication Date: 2023-12-21
Date of Acceptance: 2023-04-27
Downloads: 52 (2024), 1 (2023)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359

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