Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Knoll Machado, Steffi
Awduron Eraill: Bacher, Michael (Professor) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2023
Pynciau:
Medizin
Faktor 9
rekombinantes Protein ,
Hämophilie B
factor 9
Hemophilia B
Gerinnungsfaktor IX
Medical sciences Medicine
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2023-03593
Dyddiad Cyhoeddi: 2023-12-21
Datum der Annahme: 2023-04-27
Downloads: 52 (2024), 1 (2023)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2023/0359
https://doi.org/10.17192/z2023.0359

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