Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer
The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...
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Formato: | Dissertation |
Lenguaje: | inglés |
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Philipps-Universität Marburg
2023
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Acceso en línea: | Texto Completo PDF |
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