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Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer
The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...
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| Auteur principal: | |
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| Autres auteurs: | |
| Format: | Dissertation |
| Langue: | anglais |
| Publié: |
Philipps-Universität Marburg
2023
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| Sujets: | |
| Accès en ligne: | Texte intégral en PDF |
| Tags: |
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Internet
Texte intégral en PDF| Cote: |
urn:nbn:de:hebis:04-z2023-01780 |
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| Date de publication: |
2023-03-21 |
| Datum der Annahme: |
2023-02-07 |
| Downloads: |
119 (2024), 118 (2023) |
| Lizenz: |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
| URL d'accès: |
https://archiv.ub.uni-marburg.de/diss/z2023/0178 https://doi.org/10.17192/z2023.0178 |