Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer

Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer

The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...

Full description

Saved in:
Bibliographic Details
Main Author: Merle, Nastasja
Contributors: Stiewe, Thorsten (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
Medizin
Medical sciences Medicine
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

PDF Full Text

Holdings details from
Call Number: urn:nbn:de:hebis:04-z2023-01780
Publication Date: 2023-03-21
Date of Acceptance: 2023-02-07
Downloads: 111 (2024), 118 (2023)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2023/0178
https://doi.org/10.17192/z2023.0178

Similar Items