Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer

The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...

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Bibliografiske detaljer
Hovedforfatter: Merle, Nastasja
Andre forfattere: Stiewe, Thorsten (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprog:engelsk
Udgivet: Philipps-Universität Marburg 2023
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Klassifikationsnummer: urn:nbn:de:hebis:04-z2023-01780
Publikationsdatum: 2023-03-21
Datum der Annahme: 2023-02-07
Downloads: 119 (2024), 118 (2023)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2023/0178
https://doi.org/10.17192/z2023.0178