Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer

The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Merle, Nastasja
Awduron Eraill: Stiewe, Thorsten (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2023
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2023-01780
Dyddiad Cyhoeddi: 2023-03-21
Datum der Annahme: 2023-02-07
Downloads: 119 (2024), 118 (2023)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2023/0178
https://doi.org/10.17192/z2023.0178