Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

The design and development of a drug is complex and usually extends over many years. Different approaches can facilitate lead optimization. This work focuses on specific aspects that could lead to advances in drug discovery. After an introduction to drug design and the two studied target proteins,...

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主要作者: Sandner, Anna Sophie
其他作者: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
格式: Dissertation
语言:英语
出版: Philipps-Universität Marburg 2022
主题:
Präorganisation
secondary homeostasis
sekundäre Homöostase
Blutgerinnung
Trypsin
trypsin
preorganization
Medizin
Aldosereduktase
ligand preorganization
aldose reductase
ALR-2
Ligandenpräorganisation
blood coagulation
Thrombin
transiente Tasche
transient binding pocke
Medical sciences Medicine
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索引号: urn:nbn:de:hebis:04-z2022-01182
Publikationsdatum: 2022-05-25
Datum der Annahme: 2022-04-12
Downloads: 109 (2024), 132 (2023), 40 (2022)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
访问URL: https://archiv.ub.uni-marburg.de/diss/z2022/0118
https://doi.org/10.17192/z2022.0118

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