Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

The design and development of a drug is complex and usually extends over many years. Different approaches can facilitate lead optimization. This work focuses on specific aspects that could lead to advances in drug discovery. After an introduction to drug design and the two studied target proteins,...

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Autor principal: Sandner, Anna Sophie
Otros Autores: Klebe, Gerhard (Prof. Dr.) (Orientador)
Formato: Dissertation
Lenguaje:inglés
Publicado: Philipps-Universität Marburg 2022
Materias:
Präorganisation
secondary homeostasis
sekundäre Homöostase
Blutgerinnung
Trypsin
trypsin
preorganization
Medizin
Aldosereduktase
ligand preorganization
aldose reductase
ALR-2
Ligandenpräorganisation
blood coagulation
Thrombin
transiente Tasche
transient binding pocke
Medical sciences Medicine
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Número de Clasificación: urn:nbn:de:hebis:04-z2022-01182
Fecha de Publicación: 2022-05-25
Datum der Annahme: 2022-04-12
Downloads: 112 (2024), 132 (2023), 40 (2022)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
URL de Acceso: https://archiv.ub.uni-marburg.de/diss/z2022/0118
https://doi.org/10.17192/z2022.0118

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