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Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis
TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...
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| Natura: | Dissertation |
| Lingua: | inglese |
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Philipps-Universität Marburg
2021
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| Accesso online: | PDF Full Text |
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