Functional characterization of the TP53 mutome using CRISPR/Cas9 saturating mutagenesis

TP53 is an essential tumor suppressor gene which is inactivated in every second tumor. Most frequently TP53 is disabled by missense mutations which result in the expression of a mutant p53 protein. Mutant p53 protein is unable to prevent uncontrolled proliferation and can additionally increase cance...

Full description

Bibliographic Details

Main Author:	Klimovich, Mariia
Contributors:	Stiewe, Thorsten (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2021
Subjects:	p53 Medizin Sättigungsmutagenese CRISPR/Cas9 saturation mutagenesis Medical sciences Medicine
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!