Investigating the role of glial cells in neurodegenerative disorders by depleting astrocytes and oligodendrocytes in a model of amyloid-beta induced cytotoxicity in organotypic hippocampal slice cultures

Investigating the role of glial cells in neurodegenerative disorders by depleting astrocytes and oligodendrocytes in a model of amyloid-beta induced cytotoxicity in organotypic hippocampal slice cultures

The etiology of Alzheimer’s disease, the most common cause of dementia, is still under debate. On the molecular level, AD is characterized by the accumulation of the beta-Amyloid protein as well as neurofibrillary tangles. Additionally, evidence pinpoints to a crucial role of inflammatory processes...

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Bibliographic Details
Main Author: Vidovic, Natascha
Contributors: Dodel, Richard (Prof. Dr. med.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2020
Subjects:
Mikroglia; Astroglia; Oligodendroglia; Amyloid-beta; Schnittkulturen
Microglia; Astrocytes; Oligodendrocytes; amyloid-beta; slice cultures
Medizin
Neurodegenerative Erkrankungen; Neuroglia; Alzheimer-Krankheit; Neuroinflammation
Medical sciences Medicine
Online Access:PDF Full Text
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