Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations were done with respect to five amino acids which are believed to have an essential role in the enzyme activity and assembly....

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主要作者: Badran, Mohammed
其他作者: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
格式: Dissertation
语言:英语
出版: Philipps-Universität Marburg 2021
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