Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design
The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations were done with respect to five amino acids which are believed to have an essential role in the enzyme activity and assembly....
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Format: | Dissertation |
Sprache: | Englisch |
Veröffentlicht: |
Philipps-Universität Marburg
2021
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Schlagworte: | |
Online Zugang: | PDF-Volltext |
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PDF-VolltextSignatur: |
urn:nbn:de:hebis:04-z2021-00954 |
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Publikationsdatum: |
2021-12-02 |
Datum der Annahme: |
2020-11-06 |
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34 (2024), 129 (2023), 119 (2022), 12 (2021) |
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https://rightsstatements.org/vocab/InC-NC/1.0/ |
Zugangs-URL: |
https://archiv.ub.uni-marburg.de/diss/z2021/0095 https://doi.org/10.17192/z2021.0095 |