Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

The data presented here show that different geometries of para-alkyl substituents of a benzenesulfonamide scaffold can have a significant influence on the thermodynamic and kinetic binding parameters and suggest, that the fine-tuning of the ligand geometry to match the geometry of the active site le...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autore principale: Glöckner, Steffen
Altri autori: Klebe, Gerhard Prof. Dr. (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2020
Soggetti:
Kinetik
Isotherme Titrationskalorimetrie
Protein-ligand interactions
Proteine
Ligand
Wirkstoffdesign
Protein-Ligand-Wechselwirkungen
Proteinkristallographie
Thermodynamics
Wirkstoff
Chemie
Wechselwirkung
Kinetics
Molekulardesign
Isothermalk titration calorimetry
Kristallographie
Drug design
Mikrokalorimetrie
Protein crystallography
Thermodynamik
Chemistry & allied sciences
Accesso online:PDF Full Text
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi