Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

The data presented here show that different geometries of para-alkyl substituents of a benzenesulfonamide scaffold can have a significant influence on the thermodynamic and kinetic binding parameters and suggest, that the fine-tuning of the ligand geometry to match the geometry of the active site le...

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Bibliographic Details
Main Author: Glöckner, Steffen
Contributors: Klebe, Gerhard Prof. Dr. (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2020
Subjects:
Kinetik
Isotherme Titrationskalorimetrie
Protein-ligand interactions
Proteine
Ligand
Wirkstoffdesign
Protein-Ligand-Wechselwirkungen
Proteinkristallographie
Thermodynamics
Wirkstoff
Chemie
Wechselwirkung
Kinetics
Molekulardesign
Isothermalk titration calorimetry
Kristallographie
Drug design
Mikrokalorimetrie
Protein crystallography
Thermodynamik
Chemistry & allied sciences
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