Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

The data presented here show that different geometries of para-alkyl substituents of a benzenesulfonamide scaffold can have a significant influence on the thermodynamic and kinetic binding parameters and suggest, that the fine-tuning of the ligand geometry to match the geometry of the active site le...

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Bibliografske podrobnosti
Glavni avtor: Glöckner, Steffen
Drugi avtorji: Klebe, Gerhard Prof. Dr. (BetreuerIn (Doktorarbeit))
Format: Dissertation
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2020
Teme:
Kinetik
Isotherme Titrationskalorimetrie
Protein-ligand interactions
Proteine
Ligand
Wirkstoffdesign
Protein-Ligand-Wechselwirkungen
Proteinkristallographie
Thermodynamics
Wirkstoff
Chemie
Wechselwirkung
Kinetics
Molekulardesign
Isothermalk titration calorimetry
Kristallographie
Drug design
Mikrokalorimetrie
Protein crystallography
Thermodynamik
Chemistry & allied sciences
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Podrobnosti zaloge
Signatura: urn:nbn:de:hebis:04-z2020-01231
Publikationsdatum: 2020-12-22
Datum der Annahme: 2020-02-14
Downloads: 101 (2024), 159 (2023), 91 (2022), 55 (2021), 9 (2020)
Lizenz: https://creativecommons.org/licenses/by-nc-nd/4.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2020/0123
https://doi.org/10.17192/z2020.0123

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