Structure-based protein engineering and biochemical investigations of fungal prenyltransferases for targeted production of novel prenylated indole alkaloids

Structure-based protein engineering and biochemical investigations of fungal prenyltransferases for targeted production of novel prenylated indole alkaloids

Prenyltransferases (PTs) catalyze the transfer of one or more prenyl units with chain lengths of n x C5 (n = 1, 2 etc.) to diverse acceptors. Prenylations are essential in both the primary and secondary metabolism of all organisms. PTs are often involved in the biosynthetic pathways of secondary met...

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Détails bibliographiques
Auteur principal: Mai, Peter
Autres auteurs: Li, Shu-Ming (Prof. Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2019
Sujets:
Prenyltransferases Dimethylallyl-Transferase DMATS DMAPP GPP FPP Friedel-Crafts Alkylation Enzyme Catalysis Ascomycota Indole Alkaloids Cycl
Pharmakologie, Therapeutik
Prenyltransferasen Dimethylallyl-Transferasen DMATS DMAPP GPP FPP Friedel-Crafts Alkylierung Enzymkatalyse Schlauchpilze Indolalkaloide Cycl
Pharmacology & therapeutics, prescription drugs
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