Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Petrick, Joy Kristin

Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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Detalhes bibliográficos
Autor principal:	Petrick, Joy Kristin
Outros Autores:	Klebe, Gerhard (Prof. Dr.) (Orientador)
Formato:	Dissertation
Idioma:	inglês
Publicado em:	Philipps-Universität Marburg 2019
Assuntos:	Pharmakologie, Therapeutik mevalonate farnesyl pyrophosphate kissing bug Isoprenoid FPPS Fragment-basierte Wirkstoffforschung FDPS Chagas disease Chagas fragment based drug discovery Protein-Kristallograph protein cry isoprenoid Vernachlässigte Krankheit Farnesylpyroposphate-Synthase neglected disease Pharmacology & therapeutics, prescription drugs
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Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

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